Fig. 2

The crossover balloon occlusion technique (CBOT), in which a balloon is placed in the external iliac artery, upstream of the main TAVI access site, over the 0.018” protection wire, assures complete hemostasis during sheath removal and access closure with the pre-implanted ProGlide. In this multicenter comparative study, 229 consecutive patients treated with TAVI were divided based on the main access closure strategy in two groups: the combined (CBOT + ProGlide) and the ProGlide suture only group. The CBOT + ProGlide treated group presented lower incidence of minor vascular complications, red blood cells transfusions, Valve Academic Research Consortium-3 (VARC-3) type ≥ 2 bleeding and acute kidney injury stages ≥ 2, and reduced LOS. Even after a propensity score matching, the combined approach was associated with fewer major bleedings (CI 0.04–0.99; OR 0.2; p = 0.05). Prospective, pragmatic, randomized trials would be valuable to possibly confirm the clinical benefit of this endoclamping technique.