Fig. 6
From: Activated eosinophil plays a role in promoting fibrosis in endometriotic lesion
Hypothetical framework for fibrosis mechanism in endometriotic lesions. Hypothesis: Hypoxic environment in ovarian endometrioma induces the production of Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) from endometriotic stroma cells (ESCs) followed by the migration and activation of eosinophils. Activated eosinophils increases Plasminogen Activator Inhibitor-1 (PAI-1) expression from ESCs or endometriotic epithelial cells (EECs) and promotes the formation of fibrosis in endometriotic lesions.
