Table 1 IC50 values (µM) of UA derivatives against MCF-7 and MDA-MB-31 cells. Mean values ± sd from three independent experiments (n = 3) performed in duplicate are presented.
From: Uracil derivatives/ursolic acid hybrids - naturally derived compounds as anticancer agents
Compound | IC50 [µM] | |
|---|---|---|
MCF-7 | MDA-MB-231 | |
Ursolic acid 1 | 27.30 ± 2 | 15.04 ± 1 |
2b | > 100 | > 100 |
3b | > 100 | > 100 |
4a | 19.66 ± 2 | 12.64 ± 1 |
4b | > 100 | > 100 |
5a’ | 24.54 ± 2 | 20.42 ± 2 |
5a | 17.04 ± 1 | 9.24 ± 1 |
5b | > 100 | > 100 |
6a | 14.00 ± 1 | 5.83 ± 1 |
6b | > 100 | > 100 |
7a | 15.96 ± 1 | 19.43 ± 2 |
7b | > 100 | > 100 |
8a | 36.31 ± 2 | 33.14 ± 2 |
8b | > 100 | > 100 |
9a | 17.00 ± 2 | 12.10 ± 1 |
9a’ | 45.17 ± 2 | 58.59 ± 2 |
9b | > 100 | > 100 |
10a | > 100 | 42.06 ± 2 |
10b | > 100 | > 100 |
11a | 40.84 ± 2 | 36.31 ± 2 |
11b | > 100 | > 100 |
DOX | 3.94 ± 0.51 | 6.08 ± 0.38 |
