Table 2 The influence of new UA derivatives and reference active compound (UA) on cell proliferation in MCF-7 and MDA-MB-231 cell lines. Antiproliferative activity was measured after 24 h of incubation of cancer cells with the tested agents using a [3H]–thymidine incorporation assay. The mean values ± sd from three independent experiments (n = 6) performed in duplicate are presented.
From: Uracil derivatives/ursolic acid hybrids - naturally derived compounds as anticancer agents
Compound | IC50 [µM] | |
|---|---|---|
MCF-7 | MDA-MB-231 | |
Ursolic acid 1 | 25.72 ± 2 | 13.07 ± 1 |
2b | > 100 | > 100 |
3b | > 100 | > 100 |
4a | 18.30 ± 1 | 23.09 ± 2 |
4b | > 100 | > 100 |
5a’ | 21.69 ± 2 | 19.43 ± 2 |
5a | 16.01 ± 1 | 7.64 ± 1 |
5b | > 100 | > 100 |
6a | 16.08 ± 1 | 5.00 ± 1 |
6b | > 100 | > 100 |
7a | 18.74 ± 1 | 14.78 ± 1 |
7b | > 100 | > 100 |
8a | 34.99 ± 2 | 35.10 ± 2 |
8b | > 100 | > 100 |
9a | 16.03 ± 1 | 10.00 ± 1 |
9a’ | 47.35 ± 2 | 73.70 ± 2 |
9b | > 100 | > 100 |
10a | > 40 ± 2 | 23.53 ± 2 |
10b | > 100 | > 100 |
11a | > 40 ± 2 | 32.29 ± 2 |
11b | > 100 | > 100 |
