Table 3 IC50 [µM] values (mean ± SEM) of UA derivatives and reference compounds (UA, DOX) against human normal cells (skin fibroblasts and bronchial epithelium).
From: Uracil derivatives/ursolic acid hybrids - naturally derived compounds as anticancer agents
Compound | IC50 [µM] | |
|---|---|---|
Human skin fibroblasts | BEAS-2B | |
Ursolic acid 1 | 32.28 ± 2.46 | 16.02 ± 1.76 |
4a | 18.20 ± 2.24 | 15.93 ± 0.35 |
5a’ | 19.03 ± 2.11 | 15.71 ± 2.15 |
5a | > 100 | > 100 |
6a | 26.88 ± 1.69 | 60.22 ± 3.77 |
7a | > 100 | > 100 |
8a | 35.15 ± 2.62 | 17.54 ± 2.11 |
9a | 24.95 ± 2.34 | 16.79 ± 2.15 |
9a’ | > 100 | > 100 |
DOX | > 100 | > 100 |
