Fig. 3
Diagnostic performance of M3-score in Test Set (n = 175, AZ Delta, COVID-19 Wave 2–3, January 1 till March 22 2021). (A) Receiver Operating Characteristic (ROC) curve. (B) Violin plots of calculated M3-scores for 152 surviving patients and 23 deceased patients, with interpretative result intervals, associated likelihood ratios (LRs), and calculated posttest probabilities using mortality prevalence as the pretest probability. (C) Pie charts showing the proportion of samples categorized by LR group. Red stars indicate a statistically significant difference (p < 0.05, Chi-squared test) in patient proportions compared to Dataset 1 (UZ Brussel, Fig. 2). (D) Posttest probability curves for mortality as a function of pretest probability and M3-score result intervals. Arrows indicate posttest probabilities calculated from mortality prevalence as the pretest probability.
AUC, area under the curve; CI, confidence interval; LR, likelihood ratio; PPRE, pretest probability; PPOST, posttest probability.
