Fig. 3
Restricted Cubic Spline Models of Hazard Ratios of Fluid Resuscitation Volume Within 3 h and 28-day Mortality. (A) All patients. (B) Patients with septic shock. (C) Patients without septic shock. Knots set at the 5th, 35th, 65th, and 95th percentiles of fluid resuscitation volume. Reference is the 65th percentile. Solid lines, hazard ratios; shadow, 95% confidence interval. Model adjusted for age, sex, comorbidities (cirrhosis, cerebrovascular accidents, and hematologic malignancy), infection origin, infection site, initial sequential organ failure assessment score, lactate level, bacteremia, and treatments (steroid and source control).
