Fig. 5 | Scientific Reports

Fig. 5

From: Cudratricusxanthone A exhibits antitumor activity and enhances chemosensitivity to cisplatin against NSCLC via targeting EGFR

Fig. 5

The binding model between CTXA and EGFR. (A) Binding mode of CTXA to EGFR extracellular domain (PDB ID: 3NJP) was constructed by molecular docking. Domain I, II, III and IV of EGFR extracellular domain and EGF were respectively depicted by yellow, green, blue, pink and red cartoon. (B) The details of binding between CTXA and EGFR extracellular domain was analyzed. Key residues were displayed as sticks and colored by element type (C, green; O, red; N, blue; polar H, white.), whereas hydrogen bonds were shown as yellow dash lines. (C) 2D model of CTXA interaction of EGFR extracellular domain was shown.

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