Fig. 6 | Scientific Reports

Fig. 6

From: Cudratricusxanthone A exhibits antitumor activity and enhances chemosensitivity to cisplatin against NSCLC via targeting EGFR

Fig. 6

Molecular dynamics simulation and molecular interaction analysis of CTXA interacted with EGFR. (A) The RMSD analysis for free EGFR and the complex of CTXA and EGFR was shown. (B) The Rg analysis for free EGFR and the complex of CTXA and EGFR was observed. (C) The SASA analysis for free EGFR and the complex of CTXA and EGFR was observed. (D) The RMSF analysis for free EGFR and the complex of CTXA and EGFR was observed. (E) The number of hydrogen bonds between CTXA and EGFR extracellular domain was depicted during 30 ns. (F) Interaction between CTXA and EGFR extracellular domain was assessed by SPR technology.

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