Fig. 6
DHT IIA alleviates chondrocyte ferroptosis via activation of PPARγ in OA rats. (A) Representative immunofluorescence images of PPARγ (red) and DAPI (blue) staining in articular cartilage tissues from Normal, OA, and DHT IIA-treated rats (Scale bar: 100 μm). (B) Quantification of mean fluorescence intensity of (n = 3). (C) Immunohistochemical staining of GPX4 in rat articular cartilage (Scale bar: 100 μm). (D) Quantification of GPX4-positive cells in different groups (n = 3). (E) Representative TUNEL staining showing apoptotic chondrocytes in articular cartilage (Scale bar: 100 μm). (F) Quantification of TUNEL-positive cells in different groups (n = 3). Data are presented as mean ± SD. *p < 0.05, *p < 0.01, *p < 0.001 as indicated.
