Fig. 7
DHT IIA alleviates LPS-induced osteoarthritis through ferroptosis in a cellular model. (A) ATDC 5 cells were treated with different doses of DHT IIA for 24 h and cell viability was measured using the CCK 8 assay. (B) LPS-treated ATDC 5 cells were treated with different DHT IIA concentrations for 24 h and cell viability was measured using the CCK 8 assay. ### p < 0.001 vs. Vehicle group; * p < 0.05, ** p < 0.01, *** p < 0.001 vs. LPS group. (C, D) Western blot was performed to quantify the expression of MMP13, PPARγ, ACSL4 and COL2A1 in three groups of ATDC5 cells with different treatments. Data are represented as means ± SD. *p < 0.05; ** p < 0.01; *** p < 0.001.
