Table 2 Patient characteristics of two groups.
Characteristics | Post-progression RT (n = 26) | Upfront consolidative RT (n = 41) | P value |
|---|---|---|---|
No. (%) | No. (%) | ||
Age | |||
<60 | 11(42.3) | 24(58.8) | 0.219 |
≥ 60 | 15(57.7) | 17(41.5) | |
Gender | |||
Male | 11(42.3) | 20(48.8) | 0.626 |
Female | 15(57.7) | 21(51.2) | |
ECOG status | |||
0–1 | 25(96.2) | 38(92.7) | 0.652 |
2 | 1(3.8) | 3(7.3) | |
Histology | |||
Adenocarcinoma | 26(100) | 41(100) | - |
EGFR mutation | |||
Exon19 deletion | 9(34.6) | 17(41.5) | 0.436 |
Exon 21 L858R | 13(50) | 19(46.3) | |
Exon 18 | 1(3.8) | 4(9.8) | |
Exon 20 | 3(11.5) | 1(2.4) | |
Smoking status | |||
Yes | 12(46.2) | 16(39) | 0.617 |
No | 14(53.8) | 25(61) | |
T stage | |||
1–2 | 17(65.4) | 20(48.8) | 0.215 |
3–4 | 9(34.6) | 21(51.2) | |
N stage | |||
0–1 | 3(11.5) | 5(12.2) | 1 |
2–3 | 23(88.5) | 36(87.8) | |
M stage | |||
No | 7(26.9) | 14(34.1) | 0.598 |
Yes | 19(73.1) | 27(65.9) | |
No. of metastases | |||
0 | 7(26.9) | 14(34.1) | 0.856 |
1–2 | 11(42.3) | 16(39) | |
3–5 | 8(30.8) | 11(26.8) | |
Metastasis location | |||
Brain | |||
No | 22(84.6) | 29(70.7) | 0.247 |
Yes | 4(15.4) | 12(29.3) | |
Bone | |||
No | 17(65.4) | 29(70.7) | 0.788 |
yes | 9(34.6) | 12(29.3) | |
Adrenal | |||
No | 24(92.3) | 39(95.1) | 0.638 |
Yes | 2(7.7) | 2(4.9) | |
Liver | |||
No | 26(100) | 38(92.7) | 0.277 |
Yes | 0 | 3(7.3) | |
Pleura | |||
No | 21(80.8) | 38(92.7) | 0.245 |
Yes | 5(19.2) | 3(7.3) | |
No-regional lymph nodes | |||
No | 23(88.5) | 39(95.1) | 0.369 |
Yes | 3(11.5) | 2(4.9) | |
Radiotherapy site | |||
Lung | 21(84) | 28(68.3) | |
Bone | 3(12) | 6(14.3) | 0.525 |
Brain | 2(8) | 7(17.1) | |
TRP | |||
1–2 grades | 1(4.7%) | 3(6.5%) | 0.758 |
≥ 3 grades | 0 | 1(2.4%) | |
TKI drugs | |||
First generation | 14(53.8) | 24(58.5) | |
Second generation | 5(19.2) | 7(17.1) | 0.944 |
Third generation | 7(26.9) | 10(24.4) | |
Initial chemotherapy | |||
No | 17(65.4) | 8(43.9) | 0.132 |
Yes | 9(34.6) | 23(56.1) | |
Definitive or Palliative chemotherapy | |||
Definitive | 2(22.2%) | 9(39.1%) | 0.441 |
Palliative | 7(77.8%) | 14(60.9%) | |
Patterns of progression | |||
Local progression | 20(76.9) | 32(78.0) | 1 |
Distant metastasis | 5(19.2) | 7(17.1) | |
Progress of distant metastases | 1(3.8) | 2(4.9) | |
