Table 2 Odds ratio (weighted) for the association between METS-IR and hearing loss.

IR Surrogates	Crude Model		Model 1		Model 2
IR Surrogates	OR (95% CI)	P value	OR (95% CI)	P value	OR (95% CI)	P value
Low-frequency
Continuous	1.009(1.002–1.017)	0.014	1.014(1.005–1.024)	0.003	1.011(0.999–1.023)	0.071
Tertile 1 (< 36.3)	Reference		Reference		Reference
Tertile 2 (36.3≤&<46.6)	1.200(0.924–1.558)	0.168	1.099(0.808–1.496)	0.540	1.060(0.777–1.445)	0.707
Tertile 3 (≥ 46.6)	1.423(1.052–1.923)	0.023	1.505(1.027–2.205)	0.036	1.367(0.893–2.094)	0.146
P_trend	1.192(1.026–1.386)	0.023	1.234(1.016-1.500)	0.035	1.174(0.945–1.458)	0.148
Speech-frequency
Continuous	1.013(1.005–1.020)	0.001	1.017(1.006–1.029)	0.009	1.012(1.000-1.025)	0.048
Tertile 1 (< 36.3)	Reference		Reference		Reference
Tertile 2 (36.3≤&<46.6)	1.377(1.071–1.770)	0.013	1.273(0.908–1.783)	0.158	1.200(0.862–1.669)	0.273
Tertile 3 (≥ 46.6)	1.827(1.407–2.372)	< 0.001	2.075(1.401–3.074)	< 0.001	1.814(1.180–2.790)	0.008
P_trend	1.350(1.184–1.540)	< 0.001	1.453(1.188–1.777)	< 0.001	1.356(1.087–1.692)	0.008
High-frequency
Continuous	1.016(1.006–1.026)	0.002	1.014(1.000-1.027)	0.043	1.010(0.996–1.024)	0.161
Tertile 1 (< 36.3)	Reference		Reference		Reference
Tertile 2 (36.3≤&<46.6)	1.315(1.065–1.624)	0.012	0.903(0.640–1.276)	0.558	0.868(0.616–1.223)	0.410
Tertile 3 (≥ 46.6)	1.756(1.504–2.050)	< 0.001	1.485(1.061–2.080)	0.022	1.331(0.994–1.876)	0.100
P_trend	1.335(1.168–1.526)	< 0.001	1.236(1.043–1.466)	0.016	1.163(0.978–1.384)	0.087

Crude Model was unadjusted any covariates.
Model 1 was adjusted covariates including age, gender, and race.
Model 2 was adjusted covariates including age, gender, race, alcohol user, smoker, hypertension, diabetes, total cholesterol, ototoxic medication use, and noise exposure (firearm, occupational and off-work noise).
OR, odds ratio; CI, confident interval; METS-IR, Metabolic Score for Insulin Resistance.
Significant values are in bold.

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