Fig. 2

Pancreatic dysfunction in DIO mice is rescued by AIMD. (a) Paraffin sections of the pancreas were stained with hematoxylin and eosin (H&E) (Scale bar: 50 μm) and immunofluorescence (Scale bar: 50 μm). Green: insulin, Red: Glucagon. (b) The area of the islet within the pancreas; (c, d) Quantification of insulin and glucagon secretion in pancreatic β-cell and α-cell. Data points represent mean ± standard deviation from independent experiments, with n = 6 mice per group. Statistical significance is denoted as ^*P < 0.05, ^**P < 0.01, ^***P < 0.001 by two-way Anova with Tukey’s multiple comparisons test.