Fig. 1
From: DNA methylation patterns associated with prior tuberculosis infection in people with HIV
Epigenetic Age (DNAm) Compared to Chronological Age in Individuals with and without Prior Tuberculosis Infection. (A) Scatter plot of DNAm age (y-axis) versus chronological age (x-axis) estimated using using PCPhenoAge methylation clock. The blue dashed line represents perfect agreement between DNAm age and chronological age, while the red dashed line represents the regression line derived from the actual data. Most samples are above the blue line, indicating an overestimation of DNAm age. The bottom panel shows age acceleration values (DNAm age minus chronological age residuals), with positive values indicating accelerated aging (DNAm age > chronological age) and negative values indicating decelerated aging (DNAm age < chronological age). The results demonstrate an overall trend toward accelerated aging. (B) Box plot comparing DNAm age (Epigenetic_Age) and chronological age (Age) between individuals with previous TB infection and those without TB infection. Both groups show epigenetic ages that exceed their true age, but this over‐estimation is more pronounced in those with prior TB infection.
