Table 2 Pathway enrichment in PWH with and without prior TB from the PANTHER database.
From: DNA methylation patterns associated with prior tuberculosis infection in people with HIV
Pathway | Prior TB (both active and latent) vs. No TB | Active TB vs. No TB | Latent TB vs. No TB | Active TB vs. Latent TB |
|---|---|---|---|---|
Wnt signaling pathway | 159 genes | 38 genes | 41 genes | 60 genes |
Inflammation mediated by chemokine and cytokine signaling | 123 genes | 23 genes | 26 genes | 22 genes |
Integrin signaling pathway | 85 genes | 25 genes | 22 genes | 25 genes |
Angiogenesis | 102 genes | 19 genes | 20 genes | 18 gene |
Cadherin signaling pathway | 100 genes | 19 genes | 22 genes | 45 genes |
Heterotrimeric G-protein signaling pathway | 73 genes | 20 genes | 15 genes | 22 genes |
FGF signaling pathway | 59 genes | 17 genes | 12 genes | 9 genes |
Nicotinic Acetylcholine Receptor signaling pathway | 44 genes | 13 genes | 9 genes | 14 genes |
EGF signaling pathway | 70 genes | 14 genes | 7 genes | 12 genes |
CCKR signaling pathway | 87 genes | 19 genes | 17 genes | 21 gene |
Interleukin signaling pathway | 43 genes | 7 genes | 11 genes | 8 genes |
Apoptosis signaling pathway | 53 genes | 18 genes | 11 genes | 16 genes |
PDGF signaling pathway | 66 genes | 12 genes | 13 genes | 16 gene |
T-cell Activation | 42 genes | 5 genes | 5 genes | 9 genes |
Hedgehog signaling pathway | 11 genes | 3 genes | 3 genes | 2 genes |
Pyrimidine Metabolism | 6 genes | 3 genes | None | None |
Fructose galactose metabolism | 7 genes | None | 2 genes | None |
Histamine synthesis | None | 1 gene | None | None |
mRNA splicing | None | None | None | 1 gene |
Thiamin metabolism | None | None | None | 1 gene |
