Fig. 2 | Scientific Reports

Fig. 2

From: Inability of α-cyclodextrins to accommodate cholesterol potentially underlies their lack of efficacy and ototoxicity in Niemann-Pick disease type C treatment

Fig. 2

Effect of ICV administration of representative α-CD derivative on body weight and lifespan in NPC model mice. (A) Weekly changes in body weight (percentage over baseline at 4 weeks of age) of Npc1−/− mice. Kaplan–Meier survival curve (B) and mean lifetime (C) of untreated and HP-α-CD treated Npc1−/− mice. The experimental groups were untreated Npc1−/− mice, 21.4 µmol/kg HP-α-CD-treated Npc1−/− mice, and 42.8 µmol/kg HP-α-CD-treated Npc1−/− mice. Data represent the mean ± SEM, n = 4 for each group. ns; not significant vs. untreated group.

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