Fig. 3 | Scientific Reports

Fig. 3

From: Inability of α-cyclodextrins to accommodate cholesterol potentially underlies their lack of efficacy and ototoxicity in Niemann-Pick disease type C treatment

Fig. 3

Limited effect of α-CD derivatives on the perturbed intracellular cholesterol trafficking in NPC model cells. Concentration-dependent effects of HP-β-CD and α-CD derivatives on intracellular TC (A) and UC (B) levels, and on the EC/TC molar ratio (C) in Npc1-null cells. Cholesterol levels were measured 24 h after the exposure to 0.1, 1, and 10 mM CD. Data represent the mean ± SEM of three independent experiments performed separately for each CD derivative. *P < 0.05, **P < 0.01 vs. vehicle-treated WT cells; #P < 0.05, ##P < 0.01 vs. vehicle-treated Npc1-null cells.

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