Table 2 Volumetric and ALPS index measures according to disease stage group.

From: Multimodal MRI reveals impaired glymphatic function with choroid plexus enlargement and cerebrospinal fluid expansion in alzheimer’s disease

 

AD

(N = 28)

MCI

(N = 40)

SCD

(N = 66)

NC

(N = 54)

P值

ALPS

1.31 ± 0.173

1.48 ± 0.178

1.49 ± 0.170

1.49 ± 0.172

< 0.0001

CP volume#

1.36 ± 0.207

1.06 ± 0.202

1.00 ± 0.205

0.92 ± 0.228

< 0.0001

CSF volume#

0.31 ± 0.051

0.26 ± 0.036

0.25 ± 0.036

0.24 ± 0.033

< 0.0001

GM volume#

0.38 ± 0.027

0.41 ± 0.019

0.42 ± 0.022

0.40 ± 0.022

< 0.0001

WM volume#

0.31 ± 0.031

0.34 ± 0.023

0.34 ± 0.020

0.34 ± 0.022

< 0.0001

TIV

1434.71 ± 152.767

1464.91 ± 144.600

1460.58 ± 137.590

1472.27 ± 128.646

0.708

  1. Note.—Unless otherwise specified, data are presented as means ± standard deviations (SD). P-values reflect comparisons across all groups. Abbreviations: AD = Alzheimer’s disease, MCI = mild cognitive impairment, SCD = subjective cognitive decline, NC = normal control, ALPS = along the perivascular space, CP = choroid plexus, CSF = cerebrospinal fluid, GM = gray matter, WM = white matter, TIV = total intracranial volume.
  2. # Data represent the ratio of local volume to TIV.
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