Fig. 2 | Scientific Reports

Fig. 2

From: Druggable genome-wide Mendelian randomization integrating GWAS and eQTL/pQTL data identifies targets for lung squamous cell carcinoma

Fig. 2

Screening of LUSC-related genes using cis-pQTL. (A) Two genes are identified as risk factors (OR > 1) at the intersection of the discovery cohort (ieu_b_4953 dataset) and replication cohort (finngen_R10_c3_HEPATOCELLU-CARC-EXALLC dataset). (B) One gene is identified as protective factors (OR < 1) at the intersection of the discovery cohort (ieu_b_4953 dataset) and replication cohort (finngen_R10_c3_HEPATOCELLU-CARC-EXALLC dataset). (C) The MR analysis results of three intersecting genes in the discovery cohort. (D) The MR analysis results of three intersecting genes in the replication cohort.

Back to article page