Table 3 The effects of different doses of omega-3 supplementation on cognitive function form the nonlinear dose-response meta-analysis (standardized mean difference and 95% confidence interval).
From: A systematic review and dose response meta analysis of Omega 3 supplementation on cognitive function
Omega-3 supplementation (mg/d) | 0 (Ref) | 500 | 1000 | 1500 | 2000 | 2500 | 3000 | 3500 | 4000 | 4500 | 5000 |
|---|---|---|---|---|---|---|---|---|---|---|---|
Attention (SD) | 0 | 0.36 (-0.19, 0.92) | 0.55 (-0.16, 1.26) | 0.58 (-0.06, 1.22) | 0.47 (-0.49, 1.43) | 0.25 (-1.60, 2.09) | -0.06 (-3.10, 2.98) | -0.42 (-4.83, 3.99) | -0.80 (-6.67, 5.06) | -1.20 (-8.54, 6.15) | -1.59 (-10.4, 7.23) |
Executive functions (SD) | 0 | -0.07 (-0.55, 0.40) | -0.16 (-0.99, 0.66) | -0.27 (-2.09, 1.56) | -0.37 (-3.64, 2.89) | -0.48 (-5.32, 4.35) | -0.59 (-7.02, 5.83) | -0.70 (-8.73, 7.32) | -0.81 (-10.4, 8.81) | -0.92 (-12.1, 10.3) | -1.03 (-13.8, 11.8) |
Perceptual speed (SD) | 0 | -0.41 (-1.42, 0.60) | 1.16 (-0.30, 2.62) | 4.44 (-2.29, 11.1) | 8.56 (-4.92, 22.0) | 12.8 (-7.65, 33.3) | 17.10 (-10.3, 44.5) | 21.36 (-13.1, 55.8) | 25.6 (-15.8, 67.1) | 29.9 (-18.5, 78.3) | 34.1 (-21.3, 89.6) |
Language (SD) | 0 | 0.54 (-1.00, 2.08) | 0.85 (-1.11, 2.81) | 0.96 (-0.55, 2.47) | 0.95 (-0.23, 2.12) | 0.88 (-1.29, 3.04) | 0.81 (-2.80, 4.41) | 0.73 (-4.41, 5.87) | 0.66 (-6.03, 7.35) | 0.69 (-6.01, 8.01) | 0.65 (-5.51, 4.21) |
Episodic memory (SD) | 0 | -0.54 (-1.49, 0.41) | -0.24 (-0.98, 0.49) | 0.73 (0.13, 1.33) | 2.09 (-0.21, 4.40) | 3.56 (-0.64, 7.76) | 5.03 (-1.08, 11.1) | 6.50 (-1.52, 14.5) | 7.97 (-1.96, 17.8) | 9.44 (-2.40, 21.2) | 10.9 (-2.84, 24.6) |
Primary memory (SD) | 0 | 0.18 (-0.02, 0.38) | -0.24 (-0.98, 0.49) | 0.73 (0.13, 1.33) | 2.09 (-0.21, 4.40) | 3.56 (-0.64, 7.76) | 5.03 (-1.08, 11.1) | 6.50 (-1.52, 14.5) | 7.97 (-1.96, 17.8) | 9.44 (-2.40, 21.2) | 10.9 (-2.84, 24.6) |
Visuospatial functions (SD) | 0 | -0.03 (-0.35, 0.28) | 0.41 (0.01, 0.81) | 1.21 (-0.15, 2.58) | 2.21 (-0.50, 4.91) | 3.23 (-0.87, 7.34) | 4.26 (-1.26, 9.77) | 5.28 (-1.64, 12.2) | 6.30 (-2.02, 14.6) | 6.61 (-2.22, 12.6) | 7.21 (-3.12, 11.2) |
Global cognitive (SD) | 0 | 0.56 (0.13, 0.98) | 0.89 (0.26, 1.52) | 1.00 (0.31, 1.68) | 0.96 (0.16, 1.76) | 0.87 (-0.20, 1.94) | 0.77 (-0.66, 2.20) | 0.67 (-1.16, 2.49) | 0.57 (-1.67, 2.81) | 0.47 (-2.19, 3.13) | 0.37 (-2.71, 3.46) |
