Table 2 Clinical features of HIR < 0.4 patients and HIR ≥ 0.4 patients.

From: The hypoperfusion intensity ratio associates with APOE gene polymorphism in acute ischemic stroke patients with large vessel occlusion

 

HIR<0.4 (n = 82)

HIR ≥ 0.4 (n = 19)

P

Gender(male) (No.) (%)

54(65.85%)

13(68.42%)

0.831

Age (mean ± SD) (yr)

62.96 ± 11.28

61.74 ± 12.61

0.677

History of stroke/TIA (No.) (%)

24(29.27%)

7(36.84%)

0.519

History of cerebral hemorrhage (No.) (%)

2(2.44%)

0

1

Hypertension (No.) (%)

52(63.41%)

13(68.42%)

0.681

Diabetes (No.) (%)

22(26.83%)

7(36.84%)

0.385

Hyperlipidemia (No.) (%)

0

1(5.26%)

0.188

Coronary heart disease (No.) (%)

14(17.07%)

4(21.05%)

0.741

Atrial fibrillation (No.) (%)

11(13.41%)

3(15.79%)

0.724

Smoking (No.) (%)

26(31.71%)

5(26.32%)

0.646

Drinking (No.) (%)

7(8.54%)

1(5.26%)

1

BMI (mean ± SD)

24.08 ± 2.86

24 ± 3.12

0.912

HbA1c (median) (IQR) (%)

6.10(5.70, 7.10)

6.20(5.80, 6.70)

0.667

TC (mean ± SD) (mmol/l)

4.06 ± 1.05

3.84 ± 1.23

0.419

TG (median) (IQR) (mmol/l)

1.23(0.95, 1.71)

1.15(0.88, 1.34)

0.203

HDL-C (mean ± SD) (mmol/l)

1.04 ± 0.26

0.95 ± 0.36

0.234

LDL-C (mean ± SD) (mmol/l)

2.50 ± 0.82

2.45 ± 0.95

0.836

HCY (median) (IQR) (umol/L)

16.10(11.48, 23.48)

15.50(10.80, 21.40)

0.611

UA (median) (IQR) (umol/L)

311.96 ± 86.85

278.67 ± 72.19

0.124

HGB (median) (IQR) (g/l)

137.50(129.75, 146.25)

142(127, 155)

0.676

NIHSS (median) (IQR)

6(3, 10)

8(5, 14)

0.076

TOAST classification

 Cardioembolism

11(13.41%)

3(15.79%)

0.724

 Large-artery atherosclerosis (LAA)

71(86.59%)

16(84.21%)

 

Occluded Vessel

0.643

 ICA

12(14.63%)

3(15.79%)

 

 ICA and MCA simultaneously occluded

8(9.76%)

3(15.79%)

 

 MCA

62(75.61%)

13(68.42%)

 

APOE genotype

0.009

 ε2/ε3

9(10.98%)

0

 

 ε3/ε3

63(76.83%)

11(57.89%)

 

 ε3/ε4

9(10.98%)

8(42.11%)

 

 ε4/ε4

1(1.22%)

0

 

APOE genotype

0.013

ε3/ε3

63(86.30%)

11(57.89%)

 

 ε3/ε4

9(12.33%)

8(42.11%)

 

 ε4/ε4

1(1.37%)

0(0%)

 

APOE genotype

0.006

 non-ε4 carriers

72(87.80%)

11(57.89%)

 

 ε4 carriers

10(12.20%)

8(42.11%)

 

 IC volume (median) (IQR) (ml)

40.00(19.93, 69.47)

90.50(27.00, 176.00)

0.004

 ischemic penumbra volume (mean ± SD) (ml)

130.52 ± 70.02

164.04 ± 93.17

0.081

  1. SD, standard deviation; TIA, transient ischemic attack; BMI, Body Mass Index; HbA1c, glycated hemoglobin; IQR, interquartile range; TC, total cholesterol; TG, triglyceride; HDL-C, high density lipoprotein cholesterol; LDL-C, low density lipoprotein cholesterol; HCY, homocysteine; UA, Uric acid; HGB, hemoglobin; NIHSS, National Institutes of Health Stroke Scale; HIR, hypoperfusion intensity ratio; IC, infarct core.
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