Fig. 3
From: Metformin lotion as a novel approach to prevent tendinopathy induced by mechanical overuse
Met lotion reduces levels of inflammatory markers in mouse serum. ML decreases HMGB1 levels significantly in the serum of ITR-induced mice in a concentration-dependent manner (A). HMGB1 levels in ITR-only mice are twice as high as in mice treated with 3% ML and 3.6-fold higher than in mice with 6% ML application, with 6% ML showing greater efficacy (A). IL-1β levels in ITR mice also decrease significantly with ML application, with 6% ML being more effective than 3% (B). Similarly, ML application reduces PGE2 levels in the serum of ITR mice, with 6% ML more effective than 3% (C). The results are represented by mean ± SD from three different mice of each group (n = 3). ML: Met Lotion.
