Fig. 5
From: Metformin lotion as a novel approach to prevent tendinopathy induced by mechanical overuse
Met lotion prevents tendon degeneration during failed remodeling by enhancing collagen organization, promoting cell elongation, and enlarging enthesis size. ITR induces degenerative changes such as thinner collagen fibers, reduced enthesis size, and an increase in round-shaped chondrocyte-like cells (a–d). ML application inhibits these degenerative changes, resulting in better organized collagen fibers in the enthesis area, larger fibrocartilage tissue, and more elongated cells in the tendon tissues (e–l). b,f,j:Enlarged yellow box areas from images a,e,i. c,g,k: Enlarged red box areas from images a,e,i. d,h: Enlarged pink box areas from images c,g,k. m: Semi-quantitative results for enthesis size are reported as mean ± SD, based on five mice per group (n = 5). ML: Met Lotion. Scale bars: 500 μm (black); 100 μm (yellow); 50 μm (pink); 12.5 μm (red).
