Fig. 7
From: Metformin lotion as a novel approach to prevent tendinopathy induced by mechanical overuse
Met lotion reduces SOX-9 expression in tendons. ML application at 3% and 6% significantly decreases SOX-9 expression (e–l,m) compared to ITR alone (a–d,m), showing a 7.6-fold and 15.5-fold reduction with 3% and 6% ML application, respectively. b,f,j: Enlarged green box areas from images a,e,i. c,g,k: Enlarged orange box areas from images b,f,j. d,h,l: Enlarged yellow box areas from images c,g,k. m: Semi-quantitative results from 45 images (15 sections from 5 mice per group) are presented as mean ± SD (n = 5). ML: Met Lotion. Scale bars: 200 μm (white); 100 μm (orange); 50 μm (yellow); 12.5 μm (blue).
