Fig. 3 | Scientific Reports

Fig. 3

From: Clinical application of nanopore sequencing for haplotype linkage analysis in preimplantation genetic testing for Duchenne muscular dystrophy

Fig. 3

Resolving the carrier status of the DMD gene mutation in the embryos by nanopore sequencing mapping. SNPs haplotyping were conducted successfully using SNPs obtained by nanopore sequencing and embryonic SNPs obtained through SGS. (A) In the case of patient 1, haplotype linkage analysis revealed that embryos E2, E4, and E5 inherited the maternal DMD mutation, while embryos E1 and E3 did not inherit it. (B) For patient 2, embryos E3, E4, E5, E6, E7, and E12 were found not to have inherited the maternal DMD mutation.

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