Table 2 Correlation matrix between clinical rating scale scores and biomarkers in transfusion-dependent thalassemia patients and controls.

Biomarkers	FF	CDI	SCAS	Comp_erythron	Comp_IO
C-Reactive protein	0.496^***	0.446^**	0.295^***	-0.490^***	0.536^***
Albumin	-0.045	-0.075	-0.04	0.022	0.084
Magnesium	-0.307^***	-0.262^**	-0.12	0.319^***	-0.225^**
Calcium	-0.355^***	-0.335^**	-0.199^**	0.411^***	-0.385^***
Copper	0.424^***	0.332^**	0.315^***	-0.323^***	0.497^***
Zinc	-0.174^*	-0.204^**	-0.220^**	0.231^**	-0.078
Interleukin-6	0.194^*	0.095	0.056	-0.225^**	0.237^**
Interleukin-10	0.346^***	0.361^***	0.159^*	-0.389^***	0.375^***
Neuron-specific enolase	0.096	0.163^*	-0.083	-0.221^**	0.172^*
Glial fibrillary acidic protein	0.203^**	0.198^**	-0.018	-0.192^*	0.266^***
Neurofilament light	0.322^***	0.288^***	0.333^***	-0.361^***	0.366^***
Nestin	-0.002	-0.003	0.022	-0.055	0.144

*p < 0.05, **p < 0.01, ***p < 0.001.
Comp_erythron: composite based on hematocrit and hemoglobin, Comp_IO: composite based on iron and ferritin reflecting iron overload, FF: Fibro-Fatigue score, CDI: Children’s Depression Inventory score, SCAS: The Spence Children’s Anxiety Scale score.

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