Table 3 Results of multiple regression analysis with clinical rating scale scores as dependent variables and biomarkers as explanatory variables.

From: In transfusion-dependent thalassemia, neuronal damage biomarkers are associated with affective and chronic fatigue symptoms

Dependent Variables

Explanatory Variables

β

t

p

F model

df

p

R2

#1 Fibro-Fatigue score

Model #1

24.21

5/161

< 0.001

0.429

C-Reactive protein

0.307

4.70

< 0.001

Copper

0.270

4.16

< 0.001

Magnesium

-0.187

-2.99

0.003

Calcium

-0.169

-2.68

0.008

Neurofilament Light

0.140

2.21

0.029

#2. CDI-total score

Model #2

   

18.89

4/162

< 0.001

0.318

C-Reactive protein

0.308

4.41

0.000

Interleukin-10

0.193

2.77

0.006

Calcium

-0.197

-2.90

0.004

Neurofilament Light

0.155

2.29

0.024

#3. SCAS total score

Model #3

   

12.24

4/162

< 0.001

0.232

Neurofilament Light chain

0.214

2.93

0.004

C-Reactive Protein

0.164

2.25

0.026

Copper

0.223

3.00

0.003

Zinc

-0.191

-2.71

0.007

  1. CDI: Children’s Depression Inventory, SCAS: The Spence Children’s Anxiety Scale. R2: effect size.
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