Table 6 Exposure to two or more psychotropic drugs with CYP2D6 inhibition during pregnancy impaired neonatal short-term outcomes.

From: The impact of the number of non-opioid psychotropic medications and their co-exposures during pregnancy on short-term outcomes in full-term neonates

 

CYP2D6 inhibition (+)

N = 46

CYP2D6 inhibition (-)

N = 45

P-value

Birth Weight (g)

2940 (2154–3902)

3060 (2400–4102)

0.06

LFD

6 (13%)

8 (18%)

0.27

SGA

4 (8.7%)

2 (4.4%)

0.21

Apgar score at 1 min

8 (1–8)

8 (1–10)

0.0165*

Apgar score at 5 min

8 (4–9)

9 (5–10)

0.0153*

Umbilical artery pH

7.29 (7.15–7.38)

7.21 (6.99–7.39)

0.08

NICU admission

14(30%)

3 (6.7%)

0.0019*

Respiratory ventilator treatment

8(17%)

0 (0%)

0.0018*

NAS

7 (15%)

1 (2.2%)

0.0148*

Congenital Anomalies

2 (4.3%)

2 (4.4%)

0.49

  1. median (range) or number (%).
  2. LFD: large-for-date, SGA: small-for-gestational age, NICU: neonatal intensive care unit, NAS: neonatal abstinence syndrome, CYP: cytochrome P450.
  3. * p < 0.05.
  4. Pregnant women taking two or more psychotropic drugs into two groups: those with CYP2D6 inhibition (+) and those without [CYP2D6 inhibition (-)].
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