Table 7 Impact of the strength of CYP2D6 inhibition on neonatal short-term outcomes.

From: The impact of the number of non-opioid psychotropic medications and their co-exposures during pregnancy on short-term outcomes in full-term neonates

 

CYP2D6 inhibition (+)

Strong + Moderate

N = 18

CYP2D6 inhibition (+)

Weak

N = 20

P-value

Birth Weight (g)

2752 (2154–3902)

2970 (2372–3530)

0.44

LFD

2 (11%)

2(10%)

0.46

SGA

3 (17%)

1 (5.0%)

0.12

Apgar score at 1 min

8 (1–8)

8 (4–8)

0.0468*

Apgar score at 5 min

9 (4–9)

9 (6–9)

0.0017*

Umbilical artery pH

7.31 (7.21–7.38)

7.29 (7.15–7.38)

0.08

NICU admission

7 (39%)

5 (25%)

0.18

Respiratory ventilator treatment

4 (22%)

2 (10%)

0.15

NAS

2 (11%)

3 (15%)

0.36

Congenital Anomalies

0 (0%)

1 (5.0%)

0.17

  1. median (range) or number (%).
  2. LFD: large-for-date, SGA: small-for-gestational age, NICU: neonatal intensive care unit, NAS: neonatal abstinence syndrome, CYP: cytochrome P450.
  3. * p < 0.05.
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