Fig. 2 | Scientific Reports

Fig. 2

From: Single-cell transcriptome sequencing reveals tumor stem cells and their molecular characteristics in intrahepatic cholangiocarcinoma

Fig. 2

Identification of the characteristics of epithelial and tumor cells. (A) UMAP plots from single-cell analysis show the different “epithelial/tumor” cell clusters in the ICC and normal sample groups. (B) UMAP plots from single-cell analysis show the different epithelial cell clusters in the normal sample group. (C) UMAP plots from single-cell analysis show the different "epithelial/tumor" cell clusters in the ICC group. (D) Violin plots depicting the expression of ICC tumor marker genes KRAS and MET across different cell clusters. (E) Violin plots showing the expression of KRAS and MET in the ICC and normal sample groups. (F) UMAP plots illustrating the expression of ICC tumor marker genes KRAS and MET across different cell clusters. (G) Violin plots depicting the expression of ICC tumor marker genes KRAS and MET in different cell clusters. (H) Heatmap showing the results of CNV analysis. The upper heatmap represents the CNV profile of reference cells, while the lower heatmap represents the CNV profile of target cells. Red indicates CNV amplification, blue indicates CNV deletion and the depth of color represents the magnitude of CNV variation. (I) Box plot illustrating the CNV levels across distinct cell clusters (Mann–Whitney U test, *** p < 0.001).

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