Fig. 3 | Scientific Reports

Fig. 3

From: Antinuclear antibodies in early multiple sclerosis reflect systemic lupus erythematosus shared risk factors

Fig. 3

HLA-DRB1*15:01 and weighted Genetic Risk Scores (wGRS) for MS and SLE. Panel A and B show the distribution of the major risk allele HLA-DRB1*15:01, in total population and MS subgroup. In the total population (A), ANA-positive participants are more frequently homozygous carrier of HLA-DRB1*15:01 with a similar trend in the MS subgroup (B). Panel (C) and (F), the wGRS of MS susceptibility is shown with similar distribution between ANA+ and ANA− in total population and MS subgroup. For the wGRS of SLE, similar results are found in the total population (D) and MS subgroup (G). Panel (E) and (H) show the overlapping MS and SLE wGRS in total population and MS subgroup respectively, with no association with ANA status.

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