Fig. 4
Gating properties of the slow inactivation. (A) Closed-state inactivation in hNaV1.4/WT (–100 mV, n = 12; –80 mV, n = 7; –60 mV, n = 8) and hNaV1.4/E452K (–100 mV, n = 5; –80 mV, n = 6; –60 mV, n = 6). (B) Recovery from slow inactivation of hNaV1.4/WT (n = 7) and hNaV1.4/E452K (n = 13). (C) Onset of slow inactivation in hNaV1.4/WT (n = 4) and hNaV1.4/E452K (n = 4). All the protocols used to generate the currents are shown in the insets. The slow time constant (τSlow) was faster in hNaV1.4/E452K than in hNaV1.4/WT (*p < 0.05).
