Fig. 3 | Scientific Reports

Fig. 3

From: Design and synthesis of novel small molecules targeting the Kv1.3 voltage-gated potassium ion channel

Fig. 3

Structural design of our proposed β-carboline lead compound. The reported Kv1.3 small molecules, with areas marked for structural modifications and key pharmacophoric features: tricyclic core aromatic ring (red), aromatic substitution (green), and hydrophobic tail group (blue). The designed β-carboline lead compound, KMA, showing the three key structural features being introduced based on a scaffold hopping approach.

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