Fig. 6

Reagents and conditions: (a) Appropriate carboxylic acids, EDCI, HOBt, DCM, r.t, 16 h; (b) ArB(OH)₂, (dppf)PdCl₂, K₂CO₃, EtOH, reflux, 16 h; (c) Ph₃P, DIAD, THF, 0 °C to r.t, 16 h. Numbers in brackets denote; (6) piperidin-4-yl methanol, (7a-d) corresponding amides, (8) 3-bromophenol, (9a-d) corresponding phenols, (10a-c) target piperidine analogs.