Fig. 1

LY6H is a marker of human pancreatic delta cells. (A) Unsupervised clustering UMAP projection plot for 4 independent donors, with cell types as indicated. (B) Violin plot demonstrating expression of LY6H in the delta cells of the human pancreas as seen in scRNAseq analysis. (C) Immunofluorescence analysis of LY6H expression (green) in pancreatic sections representing control, T1D and T2D tissue donors, co-stained with antibodies recognising SOMATOSTATIN (SST, red) and CHROMOGRANIN A (CHGA, grey). Scale bars for all images are 25 μm.