Table 4 Statistical results of dose parameters for OARs in modulation factors: M1, M2, and M3.

From: A case study on optimizing helical tomotherapy parameters for small cell lung cancer with extensive pleural metastasis

 

F1

F2

F3

M1

M2

M3

p

M1

M2

M3

p

M1

M2

M3

p

Heart

Dmean

14.94 \(\pm\) 0.43

14.69 \(\pm\) 0.4

14.64 \(\pm\) 0.39

0.48

15.58 \(\pm\) 0.43

15.24 \(\pm\) 0.42

15.07 \(\pm\) 0.41

0.14

16.61 \(\pm\) 0.44

16.09 \(\pm\) 0.43

15.87 \(\pm\) 0.42

0.17

V5Gy

97.2 \(\pm\) 0.65

96.93 \(\pm\) 0.60

96.97 \(\pm\) 0.60

0.62

98.51 \(\pm\) 0.36

98.43 \(\pm\) 0.37

98.45 \(\pm\) 0.41

0.93

99.48 \(\pm\) 0.13

99.23 \(\pm\) 0.23

99.05 \(\pm\) 0.29

0.85

V25Gy

13.97 \(\pm\) 1.39

13.57 \(\pm\) 1.39

14.06 \(\pm\) 1.55

0.53

15.57 \(\pm\) 1.41

15.28 \(\pm\) 1.32

14.82 \(\pm\) 1.28

0.71

17.46 \(\pm\) 1.52

16.51 \(\pm\) 1.44

16.05 \(\pm\) 1.44

0.41

Lung-R

Dmean

19.84 \(\pm\) 0.80

19.36 \(\pm\) 0.7

19.12 \(\pm\) 0.7

0.30

20.65 \(\pm\) 0.87

20.0 \(\pm\) 0.78

19.68 \(\pm\) 0.74

0.11

21.87 \(\pm\) 0.88

21.04 \(\pm\) 0.81

20.59 \(\pm\) 0.77

0.1

V5Gy

85.81 \(\pm\) 2.48

80.74 \(\pm\) 4.31

81.67 \(\pm\) 3.22

\(<\) 0.05

90.08 \(\pm\) 1.91

87.28 \(\pm\) 2.26

85.43 \(\pm\) 2.55

\(<\) 0.05

94.24 \(\pm\) 1.53

92.43 \(\pm\) 1.74

90.96 \(\pm\) 1.86

0.29

V20Gy

45.09 \(\pm\) 2.02

43.82 \(\pm\) 1.58

43.24 \(\pm\) 1.38

0.23

46.84 \(\pm\) 2.29

45.15 \(\pm\) 1.92

44.33 \(\pm\) 1.72

0.13

50.13 \(\pm\) 2.61

47.69 \(\pm\) 2.23

46.49 \(\pm\) 2.06

0.11

V30Gy

30.74 \(\pm\) 1.63

30.53 \(\pm\) 1.50

30.48 \(\pm\) 1.45

0.98

31.71 \(\pm\) 2.11

31.03 \(\pm\) 1.89

30.78 \(\pm\) 1.79

0.65

33.19 \(\pm\) 2.30

31.88 \(\pm\) 2.06

31.33 \(\pm\) 1.97

0.3

Lung-L

Dmean

5.26 \(\pm\) 0.09

5.15 \(\pm\) 0.06

5.10 \(\pm\) 0.05

0.35

5.54 \(\pm\) 0.1

5.36 \(\pm\) 0.07

5.30 \(\pm\) 0.06

0.24

5.96 \(\pm\) 0.1

5.73 \(\pm\) 0.09

5.62 \(\pm\) 0.08

\(<\) 0.05

V5Gy

33.17 \(\pm\) 1.34

30.43 \(\pm\) 0.88

29.11 \(\pm\) 0.72

\(<\) 0.05

38.31 \(\pm\) 1.55

34.07 \(\pm\) 1.0

32.18 \(\pm\) 0.98

\(<\) 0.05

46.28 \(\pm\) 1.50

40.75 \(\pm\) 1.14

38.19 \(\pm\) 1.18

\(<\) 0.05

Lung-S

Dmean

12.38 \(\pm\) 0.21

12.10 \(\pm\) 0.15

11.96 \(\pm\) 0.13

0.25

12.91 \(\pm\) 0.23

12.51 \(\pm\) 0.18

12.32 \(\pm\) 0.16

0.12

13.73 \(\pm\) 0.22

13.18 \(\pm\) 0.19

12.93 \(\pm\) 0.17

\(<\) 0.05

V5Gy

59.10 \(\pm\) 1.07

56.27 \(\pm\) 1.03

54.75 \(\pm\) 1.05

\(<\) 0.05

63.93 \(\pm\) 0.85

60.23 \(\pm\) 0.67

58.25 \(\pm\) 0.75

\(<\) 0.05

70.12 \(\pm\) 0.52

66.26 \(\pm\) 0.25

64.13 \(\pm\) 0.24

\(<\) 0.05

V20Gy

22.73 \(\pm\) 0.29

22.26 \(\pm\) 0.21

21.98 \(\pm\) 0.21

0.11

23.64 \(\pm\) 0.43

22.91 \(\pm\) 0.31

22.54 \(\pm\) 0.28

\(<\) 0.05

25.21 \(\pm\) 0.51

24.17 \(\pm\) 0.45

23.63 \(\pm\) 0.42

\(<\) 0.05

V30Gy

15.03 \(\pm\) 0.51

14.98 \(\pm\) 0.47

14.98 \(\pm\) 0.47

0.57

15.43 \(\pm\) 0.62

15.13 \(\pm\) 0.55

15.07 \(\pm\) 0.52

0.39

16.11 \(\pm\) 0.67

15.51 \(\pm\) 0.59

15.32 \(\pm\) 0.55

0.09

SC

Dmax

34.0 \(\pm\) 0.38

33.52 \(\pm\) 0.44

33.47 \(\pm\) 0.40

0.77

33.65 \(\pm\) 0.47

33.69 \(\pm\) 0.52

33.79 \(\pm\) 0.46

0.86

34.17 \(\pm\) 0.58

33.75 \(\pm\) 0.63

33.73 \(\pm\) 0.66

0.67

Liver

Dmean

10.62 \(\pm\) 0.74

10.35 \(\pm\) 0.72

10.17 \(\pm\) 0.70

\(<\) 0.01

11.56 \(\pm\) 0.69

11.39 \(\pm\) 0.75

10.94 \(\pm\) 0.61

0.42

13.19 \(\pm\) 0.56

12.63 \(\pm\) 0.53

12.32 \(\pm\) 0.51

\(<\) 0.05

V20Gy

14.32 \(\pm\) 2.44

13.62 \(\pm\) 2.29

13.23 \(\pm\) 2.24

\(<\) 0.01

16.54 \(\pm\) 2.51

15.36 \(\pm\) 2.27

14.77 \(\pm\) 2.18

\(<\) 0.05

21.22 \(\pm\) 2.57

19.14 \(\pm\) 2.41

20.16 \(\pm\) 3.30

0.35

Eso

Dmean

20.18 \(\pm\) 2.17

20.03 \(\pm\) 2.13

19.95 \(\pm\) 2.10

0.83

21.41 \(\pm\) 2.28

21.18 \(\pm\) 2.23

21.06 \(\pm\) 2.21

0.73

23.16 \(\pm\) 2.41

22.80 \(\pm\) 2.39

22.63 \(\pm\) 2.38

0.48

  1. * Mean values \(\pm\) Standard deviation; M1: 2.4, M2: 3, M3:3.6; F1:1 cm, F2: 2.5 cm, F3: 5 cm; D* was in Gy; V*Gy was in %; Lung_R: right lung; Lung_L: left lung; Lung_S: the sum of lungs; SC: spinal cord; Eso: esophagus.