Table 6 Results of the three-factor ANOVA (FW × PF × MF) on dependent variables OARs.

From: A case study on optimizing helical tomotherapy parameters for small cell lung cancer with extensive pleural metastasis

Dependent Variables

Main effect

Interaction effect

FW

PF

MF

FW x PF

FW x MF

PW x MF

FW x PF

x MF

Freedom

(df1, df2)

(2, 81)

(2, 81)

(2, 81)

(4, 81)

(4, 81)

(4, 81)

(8, 81)

Heart

Dmean

(F, p)

(7.41,0.01)

(0.14,0.87)

(1.02,0.37)

(0.01,1.00)

(0.06,0.99)

(0.00,1.00)

(0.00,1.00)

V5Gy

(F, p)

(16.39,0.00)

(0.03,0.97)

(0.22,0.81)

(0.09,0.98)

(0.04,0.99)

(0.01,1.00)

(0.01,1.00)

V25Gy

(F, p)

(2.43,0.10)

(0.10,0.91)

(0.16,0.85)

(0.016,1.00)

(0.07,0.99)

(0.02,0.99)

(0.02,1.00)

Lung-R

Dmean

(F, p)

(3.04,0.05)

(0.06,0.95)

(1.02,0.37)

(0.00,1.00)

(0.03,0.99)

(0.00,1.00)

(0.00,1.00)

V5Gy

(F, p)

(9.19,0.00)

(0.22,0.80)

(1.74,0.01)

(0.11,0.97)

(0.12,0.98)

(0.09,0.99)

(0.09,0.99)

V20Gy

(F, p)

(2.58,0.08)

(0.03,0.97)

(1.12,0.33)

(0.01,1.00)

(0.04,0.99)

(0.00,1.00)

(0.00,1.00)

V30Gy

(F, p)

(0.43,0.65)

(0.03,0.97)

(0.19,0.82)

(0.00,1.00)

(0.04,0.99)

(0.00,1.00)

(0.00,1.00)

Lung-L

Dmean

(F, p)

(37.14,0.0)

(0.50,0.04)

(6.55,0.01)

(0.02,0.99)

(0.31,0.87)

(0.01,1.00)

(0.01,1.00)

V5Gy

(F, p)

(9.19,0.00)

(0.22,0.04)

(1.74,0.18)

(0.11,0.98)

(0.12,0.98)

(0.09,0.99)

(0.09,0.99)

Lung-S

Dmean

(F, p)

(24.09,0.00)

(0.43,0.02)

(6.97,0.00)

(0.03,0.99)

(0.23,0.92)

(0.00,1.00)

(0.00,1.00)

V5Gy

(F, p)

(107.62,0.0)

(0.71,0.03)

(30.41,0.0)

(0.02,0.99)

(0.27,0.89)

(0.02,0.99)

(0.01,1.00)

V20Gy

(F, p)

(20.02,0.00)

(0.34,0.04)

(6.52,0.00)

(0.03,0.99)

(0.29,0.88)

(0.01,1.00)

(0.01,1.00)

V30Gy

(F, p)

(0.88,0.42)

(0.09,0.05)

(0.35,0.70)

(0.01,1.00)

(0.10,0.98)

(0.00,1.00)

(0.00,1.00)

SC

Dmax

(F, p)

(0.12,0.89)

(0.39,0.68)

(0.25,0.78)

(0.06,0.99)

(0.12,0.98)

(0.02,0.99)

(0.01,1.00)

Liver

Dmean

(F, p)

(8.07,0.01)

(0.05,0.04)

(0.62,0.54)

(0.03,0.99)

(0.03,0.99)

(0.01,1.00)

(0.01,1.00)

V20Gy

(F, p)

(4.43,0.02)

(0.03,0.97)

(0.23,0.79)

(0.04,0.99)

(0.03,0.99)

(0.05,0.99)

(0.05,1.00)

Eso

Dmean

(F, p)

(0.96,0.39)

(0.01,0.99)

(0.02,0.98)

(0.00,1.00)

(0.01,1.00)

(0.00,1.00)

(0.00,1.00)

  1. * CI Conformity index, HI Homogeneity index, F F-value; df1: between-groups freedom; df2: within-groups freedom; OARs: organs at risks; D* was in Gy; V*Gy was in %; Lung_R: right lung; Lung_L: left lung; Lung_S: the sum of lungs; SC: spinal cord; Eso: esophagus.
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