Fig. 6

Setd2 cKO brains exhibit alterations in cellular populations within the hippocampus. Coronal sections taken at the level of the dentate gyrus of the hippocampus from Setd2 control (A–B'") and cKO (F–D'") brains, revealing the expression of SOX2 (red), GFAP (green) and DAPI (white). Quantification of (E) the average number of SOX2⁺ cells within the DG, (F) density of those cells in the DG, (G) average number of SOX2⁺ cells within the SGZ and H) average number of radially oriented GFAP⁺ fibres. nd = no difference, ns = not significant; ** p < 0.01. Scale bar in D'"H represents 25 µm for all large panels, and 5 µm for all insets. For all analyses, an n = 5 was used for each genotype.