Fig. 3 | Scientific Reports

Fig. 3

From: T817MA protects against inflammation and pyroptosis in response to brain ischemia via activating Sirt1 signaling

Fig. 3

T817MA inhibits neuronal pyroptosis after brain ischemia. (A) T817MA inhibits cleaved-caspase-3 expression after brain ischemia. (B) T817MA decreases the level of IL-1β after brain ischemia. (C,D) Immunostaining (C) and quantitative analysis (D) show that T817MA reduces the number of GSDMD positive neurons after brain ischemia. Scale bar = 50 μm. n = 3 (A,C,D) n = 6 (B) in each group. Data are shown as mean ± SD. #p < 0.05 vs. Sham group. *p < 0.05 vs. MCAO group.

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