Table 2 The unadjusted association between baseline variables and 30-day mortality (n = 16,691) Abbrevations: GCS, Glasgow Coma Scale; SOFA, Sequential Organ Failure Assessment; APACHE IV, Acute Physiology and Chronic Health Evaluation IV; MELD-XI, Model for End-Stage Liver Disease Excluding INR.

From: The association between the MELD-XI score and 30-day mortality in ICU patients with sepsis: a retrospective cohort study

Expoure

Statistics

Odds ratio (95% CI)

P-value

MELD-XI

17.69 ± 7.16

1.04 (1.04, 1.05)

 < 0.0001

 MELD-XI tertile

  Low

5520 (33.07%)

1.0

 

  Middle

5586 (33.47%)

1.57 (1.41, 1.75)

 < 0.0001

  High

5585 (33.46%)

1.99 (1.79, 2.21)

 < 0.0001

 Ethnicity

  African American

1770 (10.69%)

1.0

 

  Asian

284 (1.71%)

1.43 (1.04, 1.96)

0.0261

  Caucasian

12,829 (77.47%)

1.09 (0.95, 1.25)

0.2414

  Hispanic

728 (4.40%)

1.08 (0.85, 1.37)

0.5257

  Native American

134 (0.81%)

1.28 (0.81, 2.01)

0.2864

  Other/Unknown

815 (4.92%)

0.90 (0.71, 1.14)

0.3752

 Gender

  Female

7859 (47.09%)

1.0

 

  Male

8829 (52.91%)

1.07 (0.98, 1.16)

0.1152

  Age

65.0 ± 15.96

1.02 (1.02, 1.02)

 < 0.0001

Total Bilirubin

1.71 ± 2.63

1.08 (1.06, 1.09)

 < 0.0001

Creatinine

1.97 ± 1.08

1.21 (1.17, 1.26)

 < 0.0001

Lactate

3.33 ± 3.08

1.15 (1.13, 1.16)

 < 0.0001

Pulmonary Infection

6967 (41.74%)

1.18 (1.09, 1.28)

 < 0.0001

Renal/urinary tract infection

1676 (10.04%)

0.88 (0.76, 1.01)

0.0685

Skin/Bone/joint Infection

1129 (6.76%)

0.74 (0.62, 0.89)

0.0012

Gastrointestinal/Intra-abdominal Infection

1043 (6.25%)

1.12 (0.95, 1.33)

0.1650

Septic shock

7368 (44.14%)

1.30 (1.19, 1.41)

 < 0.0001

APACHE IV

73.12 ± 27.32

1.03 (1.02, 1.03)

 < 0.00001

SOFA

8.06 ± 3.59

1.24 (1.23, 1.26)

 < 0.00001

GCS

9.59 ± 4.37

0.81 (0.80, 0.82)

 < 0.00001

Congestive heart failure

3165 (18.96%)

1.09 (0.98, 1.21)

0.0949

Cardiac arrhythmias

3405 (20.40%)

1.42 (1.29, 1.57)

 < 0.0001

Severe liver disease

462 (2.77%)

2.12 (1.72, 2.60)

 < 0.0001

Renal failure

2540 (15.22%)

1.21 (1.08, 1.35)

0.0007

Malignant cancer

2483 (14.88%)

1.59 (1.43, 1.77)

 < 0.0001

Metastatic solid tumor

512 (3.07%)

2.57 (2.13, 3.11)

 < 0.0001

History of dialysis

964 (5.78%)

0.71 (0.58, 0.86)

0.0006

  1. Values in bold indicate statistical significance at P < 0.05.