Table 3 Univariate and multivariate Cox regression for cancer-specific survival and overall survival.

From: The effect of marital status on cervical cancer related prognosis: a propensity score matching study

Characteristic

Cancer-specific survival

Overall survival

Univariate

Multivariate

Univariate

Multivariate

HR (95% CI)

p-value

HR (95% CI)

p-value

HR (95% CI)

p-value

HR (95% CI)

p-value

Year of diagnosis

 2000–2008

Ref

 

Ref

 

Ref

 

Ref

 

 2009–2017

0.88 (0.84, 0.92)

< 0.001

0.86 (0.82, 0.90)

< 0.001

0.88 (0.84, 0.92)

< 0.001

0.87 (0.83, 0.91)

< 0.001

Age

 < 45 years

Ref

 

Ref

 

Ref

 

Ref

 

 45–60 years

1.87 (1.77, 1.97)

< 0.001

1.18 (1.11, 1.25)

< 0.001

2.03 (1.93, 2.14)

< 0.001

1.37 (1.30, 1.45)

< 0.001

 > 60 years

2.65 (2.49, 2.82)

< 0.001

1.46 (1.36, 1.56)

< 0.001

3.60 (3.40, 3.80)

< 0.001

2.14 (2.02, 2.27)

< 0.001

Marital status

 Married

Ref

 

Ref

 

Ref

 

Ref

 

 Unmarried

1.07 (1.02, 1.13)

0.003

1.12 (1.07, 1.17)

< 0.001

1.13 (1.08, 1.18)

< 0.001

1.19 (1.14, 1.24)

< 0.001

Race

 White

Ref

 

Ref

 

Ref

 

Ref

 

 Black

1.28 (1.19, 1.39)

< 0.001

1.14 (1.05, 1.24)

0.001

1.34 (1.25, 1.44)

< 0.001

1.17 (1.09, 1.26)

< 0.001

 Other

1.10 (1.02, 1.19)

0.019

0.90 (0.83, 0.98)

0.013

1.08 (1.00, 1.16)

0.037

0.84 (0.78, 0.91)

< 0.001

Ethnicity

 Hispanic

Ref

 

Ref

 

Ref

 

Ref

 

 Non-Hisp

1.24 (1.17, 1.31)

< 0.001

1.17 (1.10, 1.24)

< 0.001

1.34 (1.27, 1.41)

< 0.001

1.24 (1.17, 1.31)

< 0.001

Median household income

 < 75,000USD

Ref

 

Ref

 

Ref

 

Ref

 

 ≥ 75,000USD

0.89 (0.85, 0.94)

< 0.001

0.94 (0.90, 0.99)

0.026

0.88 (0.85, 0.92)

< 0.001

0.93 (0.89, 0.97)

0.001

Residence

 Urban

Ref

 

Ref

 

Ref

 

Ref

 

 Rural

1.22 (1.14, 1.31)

< 0.001

1.01 (0.94, 1.09)

0.719

1.29 (1.21, 1.37)

< 0.001

1.06 (0.99, 1.13)

0.114

Histology

 SCC

Ref

 

Ref

 

Ref

 

Ref

 

 AC

0.71 (0.66, 0.75)

< 0.001

1.20 (1.12, 1.28)

< 0.001

0.69 (0.66, 0.74)

< 0.001

1.12 (1.05, 1.19)

< 0.001

 Others

1.49 (1.39, 1.60)

< 0.001

1.59 (1.47, 1.71)

< 0.001

1.35 (1.26, 1.44)

< 0.001

1.48 (1.38, 1.58)

< 0.001

Grade

 Well

Ref

 

Ref

 

Ref

 

Ref

 

 Moderately

2.71 (2.41, 3.06)

< 0.001

1.61 (1.43, 1.82)

< 0.001

2.31 (2.09, 2.54)

< 0.001

1.45 (1.32, 1.61)

< 0.001

 Poorly/Undiff

5.02 (4.47, 5.63)

< 0.001

2.22 (1.97, 2.51)

< 0.001

3.98 (3.62, 4.38)

< 0.001

1.96 (1.77, 2.16)

< 0.001

Stage

 Localized

Ref

 

Ref

 

Ref

 

Ref

 

 Regional

5.45 (5.09, 5.84)

< 0.001

3.57 (3.27, 3.89)

< 0.001

4.01 (3.79, 4.23)

< 0.001

2.54 (2.37, 2.72)

< 0.001

 Distant

20.39 (18.92, 21.97)

< 0.001

11.53 (10.50, 12.66)

< 0.001

13.90 (13.04, 14.81)

< 0.001

7.64 (7.06, 8.27)

< 0.001

Surgery

 Performed

Ref

 

Ref

 

Ref

 

Ref

 

 Not performed

4.59 (4.36, 4.82)

< 0.001

2.05 (1.93, 2.17)

< 0.001

4.16 (3.98, 4.35)

< 0.001

2.04 (1.93, 2.16)

< 0.001

Radiotherapy

 Yes

Ref

 

Ref

 

Ref

 

Ref

 

 No

0.27 (0.26, 0.29)

< 0.001

0.93 (0.85, 1.00)

0.062

0.31 (0.29, 0.32)

< 0.001

0.87 (0.81, 0.93)

< 0.001

Chemotherapy

 Yes

Ref

 

Ref

 

Ref

 

Ref

 

 No/Unknown

0.27 (0.26, 0.29)

< 0.001

1.19 (1.11, 1.29)

< 0.001

0.34 (0.32, 0.36)

< 0.001

1.28 (1.20, 1.37)

< 0.001

  1. HR, hazard ratio; CI, confidence interval.
  2. Bold indicates marital status is an independent prognostic factor for cancer-specific survival and overall survival.
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