Fig. 2
Kaplan-Meier curves of incidence of acute exacerbation of idiopathic interstitial pneumonia (AE-IIP). The incidence of AE was significantly higher in patients with lower %FVC (A, p = 0.019; divided by the median value) and in those positive for anti-CCP antibody (D), (p = 0.006). The incidence of AE was lower in patients positive for PM/DM- or SSc-related antibodies, or ANA ≥ 320 (E, (p = 0.019). Patients with higher %DLCO (B), (p = 0.116) or those meeting IPAF criteria (C), p = 0.218) tended to have lower incidence of AE-IIP. The p-values were determined using Gray’s test. PM/DM- and SSc-related antibodies included anti-ARS antibody, anti-Jo-1 antibody, anti-Scl70 antibody, anti-RNP antibody, anti-RNA polymerase III antibody, and anti-centromere antibody. FVC, forced vital capacity; AE, acute exacerbation; IIP, idiopathic interstitial pneumonia; ANA, antinuclear antibody; CCP, cyclic citrullinated peptide; ARS, aminoacyl tRNA synthetase; PM/DM, polymyositis/dermatomyositis; SSc, systemic sclerosis; DLCO, carbon monoxide diffusion lung capacity.
