Table 1 Patient characteristics.

From: Efficacy and safety of combination immunotherapy for treating advanced non-clear cell renal cell carcinoma: A multicenter retrospective study in Japan

 

nccRCC group

(n = 21)

cc-RCC group

(n = 165)

p

Age

(year, median, IQR)

60.0

(55.0–73.0)

67.0

(58.0–72.0)

0.568

Sex (number, %)

Male

13 (61.9)

125 (75.8)

0.271

Female

8 (38.1)

40 (24.2)

IMDC risk classification (number, %)

Favorable risk

1 (4.8)

17 (10.3)

0.717

Intermediate risk

14 (66.7)

102 (61.8)

Poor risk

6 (28.6)

46 (27.9)

Histological type (number, %)

Clear cell

0

165 (100)

 

Papillary

15 (71.4)

0

 

Chromophobe

2 (9.5)

0

 

Acuired cystic disease-associated

2 (9.5)

0

 

MiT family translocation

1 (4.8)

0

 

Fumarate hydratase deficient

1 (4.8)

0

 

Sarcomatoid feature (number, %)

3 (14.3)

16 (9.8)

0.793

Fuhrman grade (Number, %)

1

0

14 (8.5)

 

2

2 (9.5)

52 (31.5)

 

3

10 (47.6)

34 (20.6)

 

4

3 (14.3)

19 (11.5)

 

Unknown

6 (28.6)

46 (27.9)

 

Number of metastatic sites (number, %)

0

1 (4.7)

15 (9.1)

0.918

1

9 (42.9)

73 (44.2)

≥ 2

11 (52.4)

77 (46.7)

The metastatic sites (number, %)

Lymph node

9 (42.9)

49 (29.7)

0.329

Lung

10 (47.6)

109 (66.1)

0.157

Bone

5 (23.8)

53 (32.1)

0.600

Liver

6 (28.6)

16 (9.7)

0.030

Brain

1 (4.8)

12 (7.3)

> 0.999

The number of patients performed with nephrectomy before treatment

(number, %)

15 (71.4)

88 (53.3)

0.181

The number of patients with deferred cytoreductive nephrectomy (number, %)

3 (14.3)

10 (6.1)

0.348

Follow-up period

(year, median, IQR)

17.7

(4.4–24.8)

20.4

(9.9–35.0)

0.108

  1. Abbreviations: cc-RCC = Clear cell renal cell carcinoma; IMDC = The International Metastatic Renal Cell Carcinoma Database Consortium; IQR = Interquartile range; nccRCC = Non-clear cell renal cell carcinoma.