Table 4 Treatment-related adverse events of first line treatment.
nccRCC group | cc-RCC group | |||||||
|---|---|---|---|---|---|---|---|---|
ICI + ICI (n = 11) | ICI + TKI (n = 10) | ICI + ICI (n = 88) | ICI + TKI (n = 77) | |||||
Event (Number, %) | All grades | Grade 3/4 | All grades | Grade 3/4 | All grades | Grade 3/4 | All grades | Grade 3/4 |
Any events | 8 (72.7) | 1 (9.1) | 10 (100) | 4 (40.0) | 66 (75.0) | 19 (21.6) | 70 (90.9) | 25 (32.5) |
Erythema multiforme | 1 (9.1) | 0 | 0 | 0 | 12 (13.6) | 3 (3.4) | 4 (5.2) | 0 |
Hepatic failure | 0 | 0 | 1 (10.0) | 1 (10.0) | 6 (6.8) | 3 (3.4) | 9 (11.7) | 4 (5.2) |
Pneumonitis | 2 (18.2) | 1 (9.1) | 0 | 0 | 14 (15.9) | 2 (2.3) | 1 (1.3) | 0 |
Hypothyroidism | 1 (9.1) | 0 | 0 | 0 | 5 (5.7) | 0 | 8 (10.4) | 0 |
Adrenal insufficiency | 0 | 0 | 0 | 0 | 9 (10.2) | 4 (4.5) | 2 (2.6) | 2 (2.6) |
Hypertension | 0 | 0 | 3 (30.0) | 1 (10.0) | 0 | 0 | 10 (13.0) | 5 (6.5) |
Proteinuria | 0 | 0 | 0 | 0 | 0 | 0 | 9 (11.7) | 3 (3.9) |
Colitis | 0 | 0 | 0 | 0 | 3 (3.4) | 3 (3.4) | 4 (5.2) | 1 (1.3) |
Hypopituitarism | 1 (9.1) | 0 | 0 | 0 | 5 (5.7) | 1 (1.1) | 2 (2.6) | 1 (1.3) |
Malaise | 0 | 0 | 0 | 0 | 0 | 0 | 4 (5.2) | 3 (3.9) |
Palmar-plantar erythrodysesthesia syndrome | 0 | 0 | 2 (20.0) | 0 | 0 | 0 | 3 (3.9) | 0 |
Injection site reaction | 1 (9.1) | 0 | 0 | 0 | 1 (1.1) | 0 | 2 (2.6) | 0 |
Pruritus | 0 | 0 | 0 | 0 | 2 (2.3) | 0 | 0 | 0 |
Vision decreased | 0 | 0 | 0 | 0 | 1 (1.1) | 0 | 1 (1.3) | 0 |
Hyperthyroidism | 1 (9.1) | 0 | 0 | 0 | 2 (2.3) | 0 | 0 | 0 |
Pancreatitis | 1 (9.1) | 0 | 0 | 0 | 1 (1.1) | 1 (1.1) | 1 (1.3) | 1 (1.3) |
Heart failure | 0 | 0 | 0 | 0 | 0 | 0 | 2 (2.6) | 0 |
Colonic obstruction | 0 | 0 | 0 | 0 | 1 (1.1) | 1 (1.1) | 0 | 0 |
Nervous system disorders | 0 | 0 | 0 | 0 | 1 (1.1) | 1 (1.1) | 0 | 0 |
Arthritis | 0 | 0 | 0 | 0 | 1 (1.1) | 0 | 0 | 0 |
Oropharyngeal pain | 0 | 0 | 0 | 0 | 0 | 0 | 1 (1.3) | 0 |
Dysgeusia | 0 | 0 | 0 | 0 | 0 | 0 | 1 (1.3) | 0 |
Platelet count decreased | 0 | 0 | 1 (10.0) | 0 | 0 | 0 | 1 (1.3) | 1 (1.3) |
Colonic perforation | 0 | 0 | 0 | 0 | 0 | 0 | 1 (1.3) | 1 (1.3) |
Toxic epidermal necrolysis | 0 | 0 | 0 | 0 | 1 (1.1) | 0 | 0 | 0 |
Soft tissue infection | 0 | 0 | 0 | 0 | 0 | 0 | 1 (1.3) | 1 (1.3) |
Cholecystitis | 0 | 0 | 1 (10.0) | 1 (10.0) | 0 | 0 | 0 | 0 |
Others | 0 | 0 | 2 (20.0) | 1 (10.0) | 0 | 0 | 3 (3.9) | 2 (2.6) |
