Fig. 1
From: Dynamic alterations of oral fungal microbiota in Omicron infected patients
Participant flow diagram. We collected 963 tongue coating samples in this study, 336 samples from PIOV, 234 samples from RP, 71 samples from PIOS, 299 samples from HC. After the quality control, a total of 940 tongue samples (336 PIOV, 234 RP, 71 PIOS, 299 HC) completed ITS sequencing. We compared the difference of oral fungal microorganisms between PIOV, RP and HC, to analyze the dynamic characteristics of oral fungi in omicron infected patients during their recovery. And compared the oral fungal characteristics of PIOV with PIOS. Finally, we randomly divided PIOV and HC into training set and validation set at the ratio of 2:1. The best oral fungal microbial markers were identified in the training cohort, and the diagnostic model of PIOV was constructed for verification in the test cohort. Meanwhile, we collected blood samples from HC and PIOV to compare their liver and kidney function and routine blood. PIOV, patients infected Omicron variant; RP, recovered patients infected Omicron; PIOS, patients infected original strain of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2); HC, healthy control; ITS, internal transcribed spacer.
