Fig. 3
From: Persistent open chromatin state in early-life stress-activated cells of the VTA
Chromatin opening after ELS predicts gene expression in response to adult stress. (a) log2(fold change) of genes putatively contacted by CRE-DARs after adult stress alone (Std-AS) compared to Std-control or ELS and adult stress together (ELS-AS) compared to ELS-controls. (b) Gene Ontology (GO) terms for gene list putatively contacted by ELS-opened DARs for biological process. (c,d) Example gene expression in Std-AS (vs. Std-Ctl) and ELS-AS (vs. ELS-Ctl) for Ampd2 (c) and Slco4a1 (d). Left: normalized gene expression for both males (circles) and females (triangles); right: browser tracks showing each CRE-DAR and putative gene contact (yellow highlights).
