Fig. 1

Study design overview: three tobacco-free nicotine pouch products (zoneX #5 (16 mg nicotine/ pouch), zoneX #5 slim (14 mg) and zoneX #6 (20 mg)) and one Skruf tobacco-containing snus product (16.6 mg nicotine/ pouch) were randomised to 27 subjects for assessments across four days. h: hours; PK: pharmacokinetic.