Table 2 Statistical comparisons for the baseline adjusted nicotine pharmacokinetic (PK) parameters. Values in milligrams (mg) refer to pouch nicotine content.

From: Evaluation of high-nicotine oral products shows potential to reduce tobacco-related harm by offering satisfying alternatives

PK variable

Test product (mg)

Reference product

95% CI lower bound

Ratio of geometric LS means

95% CI upper bound

Tukey–Kramer adjusted p value

Cmax

(ng/ml)

#5 14

Skruf

0.89

1.06

1.25

0.828

#5 14

#5 16 mg

0.93

1.10

1.30

0.469

#5 14

#6 20 mg

0.66

0.78

0.93

0.002*

#5 16

Skruf

0.81

0.96

1.14

0.931

#5 16

#6 20 mg

0.60

0.71

0.84

 < 0.0001*

#6 20

Skruf

1.14

1.35

1.60

 < 0.0001*

AUCt (h*ng/ml)

#5 14

Skruf

0.98

1.10

1.24

0.145

#5 14

#5 16 mg

0.98

1.10

1.24

0.146

#5 14

#6 20 mg

0.68

0.76

0.86

 < 0.0001*

#5 16

Skruf

0.89

1.00

1.13

1.000

#5 16

#6 20 mg

0.61

0.69

0.78

 < 0.0001*

#6 20

Skruf

1.28

1.45

1.63

 < 0.0001*

AUC0-inf (h*ng/ml)

#5 14

Skruf

0.98

1.10

1.23

0.159

#5 14

#5 16 mg

0.97

1.09

1.22

0.233

#5 14

#6 20 mg

0.68

0.77

0.86

 < 0.0001*

#5 16

Skruf

0.90

1.01

1.13

0.997

#5 16

#6 20 mg

0.63

0.71

0.79

 < 0.0001*

#6 20

Skruf

1.27

1.43

1.60

 < 0.0001*

  1. AUC0-inf: AUC from timepoint 0 to infinity; AUCt: area under the plasma concentration–time curve from time 0 to the time of the last sampling timepoint; CI: confidence interval; Cmax: maximum observed plasma concentration; LS: least square. *significant difference.
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