Table 2 Summary of the PPI network Clusters.
Nodes | Edges | Genes | Functional enrichment analysis (GO-BP) | |
|---|---|---|---|---|
PPI network | 73 | 481 | ABCB1, AFP, AKR1B1, AKT1, ALB, ANXA5, APEX1, BAD, BAK1, BAX, BCL2, BCL2L1, BIRC5, CASP1, CASP3, CASP8, CASP9, CCNA2, CCND1, CDK1, CDK2, CDK4, CDK6, CDKN2A, CFTR, COMT, CTNNB1, CYCS, CYP1A1, CYP2E1, DNASE1, EGFR, EHMT2, ESR1, GADD45A, GFAP, GGT1, GSR, GSTA1, GSTP1, HMOX1, HSF1, HSP90AA1, HSPA4, HSPA8, HSPB1, IGF1R, IL1B, IL2, KDR, LOX, MAPK1, MAPK14, MAPK3, MAPK8, MBP, MET, MMP3, MPO, NFE2L2, NQO1, NR3C1, PARP1, PRKCD, PTGS2, SOD1, SRC, STAT3, TNF, TYR, UGT1A1, WRN, XDH | Regulation of apoptotic Process Negative regulation of apoptotic Process Negative regulation of programmed cell death |
Cluster 1 | 22 | 177 | TNF, CYCS, IL1B, EGFR, BCL2, MAPK14, CCND1, ANXA5, AKT1, MAPK3, ESR1, CASP9, PARP1, PTGS2, CASP8, BCL2L1, CTNNB1, SRC, MAPK8, HSPA4, CASP3, STAT3 | Regulation of apoptotic process |
Cluster 2 | 4 | 6 | GGT1, GSTA1, GSTP1, GSR | Glutathione metabolic process |
Cluster 3 | 5 | 7 | BIRC5, CDK4, CCNA2, CDK6, CDK1 | Mitotic cell cycle phase transition |
Cluster 4 | 4 | 5 | HSF1, HSPA8, CFTR, HSPB1 | Response to Unfolded Protein |
